Apolipoprotein E in Cerebrospinal Fluid: Relation to Phenotype and Plasma Apolipoprotein E Concentrations
نویسندگان
چکیده
منابع مشابه
Apolipoprotein E in cerebrospinal fluid: relation to phenotype and plasma apolipoprotein E concentrations.
BACKGROUND Apolipoprotein (apo) E may be related to the development of Alzheimer disease, but data on apoE in cerebrospinal fluid (CSF) are limited. The aim of the present study was to measure apoE in CSF and relate its concentrations to apoE phenotype and CSF lipids. METHODS We adapted an assay for CSF apoE sensitivity using an ELISA. It allowed us to measure CSF apoE with sufficient reprodu...
متن کاملCerebrospinal Fluid Apolipoprotein E Levels in Delirium
BACKGROUND/AIMS Delirium and the apolipoprotein E ε4 allele are risk factors for late-onset Alzheimer disease (LOAD), but the connection is unclear. We looked for an association. METHODS Inpatients with delirium (n = 18) were compared with LOAD outpatients (n = 19), assaying blood and cerebrospinal fluid (CSF) using multiplex ELISA. RESULTS The patients with delirium had a higher Confusion ...
متن کاملCharacterization of apolipoprotein E-containing lipoproteins in cerebrospinal fluid: effect of phenotype on the distribution of apolipoprotein E.
BACKGROUND Apolipoprotein (apo) E, one of the main apolipoproteins in the central nervous system, may play an important role in lipid metabolism; however, the details of its function are poorly understood. In this study, we characterized apoE-containing lipoproteins in cerebrospinal fluid (CSF) and examined the effect of apoE phenotype on the distribution of apoE among the lipoprotein fractions...
متن کاملCerebrospinal fluid apolipoprotein E concentration decreases after seizure
PURPOSE In epilepsy, many studies were focus on apoE gene polymorphism and found APOE epsilon4 to be associated with earlier onset of temporal lobe epilepsy. There is not any study about apoE in cerebrospinal fluid (CSF) of epileptic patients, so we detect the CSF-apoE and determine whether it is changed after seizure. METHODS A total of 60 epileptic patients and 28 subjects with no evidence ...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 1999
ISSN: 0009-9147,1530-8561
DOI: 10.1093/clinchem/45.4.497